Designated on February 11, 2016, Mojave Trails National Monument provides more that 1.6 million acres of vital habitat for sensitive wildlife and unspoiled desert vistas, including 350,000 acres of Congressionally designated Wilderness. It protects sacred Native American trails and trade routes; the longest undeveloped stretch of historic Route 66; ancient lava flows; trilobite fossil beds; and many unique historic and scientific features. Mojave Trails also represents the largest land gift in American history, with over 200,000 private acres donated to the BLM for conservation in perpetuity.

This area has been championed by Friends Grassroots Network members Mojave Desert Land Trust and the Amargosa Conservancy.